Missi Pyle was born on November 16, 1972 as Andrea Kay Pyle in Houston, Texas and was raised in Memphis, Tennessee. The daughter of Linda and Frank Pyle, she has four older siblings, sisters Debbie and Julie, and brothers Sam and Paul. Pyle attended the North Carolina School of the Arts and graduated in 1995. Since then, Pyle has had a significant career in many films and television series.
Pyle began a career as a singer when she met Shawnee Smith in 2007 while filming an ABC comedy pilot. Pyle stated that her dream was to be in a rock band, and Smith gave her the opportunity by creating the country-rock band Smith & Pyle in Los Angeles, California. Their debut album "It's OK to Be Happy" was recorded in Joshua Tree, California and was released in 2008 under their own record label when they became business partners. Their first live performance was in Texas on January 18, 2008 and since then, the band performed in many other states, especially in West Virginia, until May 29, 2010 in California. In 2011, the actresses officially disbanded before their second album was completed.